Reaction Details |
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Target | Lysosomal acid glucosylceramidase |
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Ligand | BDBM285819 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Assay for Determination of Ki Values for Inhibition of GCase Activity |
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pH | 7±n/a |
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Ki | 2.60±n/a nM |
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Comments | extracted |
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Citation | Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Glucocerebrosidase modulators and uses thereof US Patent US10081601 Publication Date 9/25/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Lysosomal acid glucosylceramidase |
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Name: | Lysosomal acid glucosylceramidase |
Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
Type: | Enzyme |
Mol. Mass.: | 59724.64 |
Organism: | Homo sapiens (Human) |
Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
Residue: | 536 |
Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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BDBM285819 |
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n/a |
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Name | BDBM285819 |
Synonyms: | (6R,7R,8S)-8-methyl-4-azaspiro[2.5]octane-6,7-diol | US10081601, Example 1 | US9796680, Example 1 |
Type | Small organic molecule |
Emp. Form. | C8H15NO2 |
Mol. Mass. | 157.2102 |
SMILES | C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 |r| |
Structure |
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