Reaction Details |
| Report a problem with these data |
Target | Lysosomal acid glucosylceramidase |
---|
Ligand | BDBM285822 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Assay for Determination of Ki Values for Inhibition of GCase Activity |
---|
pH | 7±n/a |
---|
Ki | 8.00±n/a nM |
---|
Comments | extracted |
---|
Citation | Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Glucocerebrosidase modulators and uses thereof US Patent US10081601 Publication Date 9/25/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Lysosomal acid glucosylceramidase |
---|
Name: | Lysosomal acid glucosylceramidase |
Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
Type: | Enzyme |
Mol. Mass.: | 59724.64 |
Organism: | Homo sapiens (Human) |
Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
Residue: | 536 |
Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
|
|
|
BDBM285822 |
---|
n/a |
---|
Name | BDBM285822 |
Synonyms: | (6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octane-6,7-diol | US10081601, Example 4 | US9796680, Example 4 |
Type | Small organic molecule |
Emp. Form. | C8H13F2NO2 |
Mol. Mass. | 193.1911 |
SMILES | O[C@@H]1CNC2(CC2)[C@H](C(F)F)[C@H]1O |r| |
Structure |
|