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TargetSteroid 17-alpha-hydroxylase/17,20 lyase
LigandBDBM140958
Substrate/Competitorn/a
Meas. Tech.Total SPA Assay
pH7.2±n/a
Temperature277.15±n/a K
IC50 1.4±n/a nM
Commentsextracted
Citation Austin, JFSharma, LSBalog, JAHuang, AVelaparthi, UDarne, CPSaulnier, MG Sulfonamide compounds useful as CYP17 inhibitors US Patent US8916553 Publication Date 12/23/2014
More Info.:Get all data from this article,  Assay Method
 
Steroid 17-alpha-hydroxylase/17,20 lyase
Name:Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:CP17A_HUMAN | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450 C17 (CYP17 ) | Cytochrome P450 C17 (CYP17) | Cytochrome P450 CYP17 | Cytochrome P450-C17 | Cytochrome P450-C17 (CYP17) | P450-C17 | S17AH | Steroid 17-alpha-Monooxygenase (CYP17) | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase | cytochrome P450 monooxygenase 17 alpha hydroxylase/17,20-lyase (CYP17)
Type:Enzyme
Mol. Mass.:57382.42
Organism:Homo sapiens (Human)
Description:E.coli expressing human CYP17
Residue:508
Sequence:
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
KVVFLIDSFKVKIKVRQAWREAQAEGST
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  Blast E-value cutoff:
BDBM140958
n/a
NameBDBM140958
Synonyms:US8916553, 198
TypeSmall organic molecule
Emp. Form.C15H15F3N2O3S
Mol. Mass.360.351
SMILESCc1cc(NS(C)(=O)=O)ccc1-c1cnccc1OCC(F)(F)F
Structure
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