| Reaction Details |
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 | Report a problem with these data |
| Target | Integrin alpha-5 |
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| Ligand | BDBM141973 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| pH | 9.6±n/a |
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| Temperature | 277.15±n/a K |
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| IC50 | <100±n/a nM |
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| Comments | extracted |
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| Citation |  Zischinsky, G; Stragies, R; Osterkamp, F; Scharn, D; Hummel, G; Kalkhof, H; Zahn, G; Vossmeyer, D; Christner-Albrecht, C; Reineke, U Compounds for the inhibition of integrins and use thereof US Patent US8927534 Publication Date 1/6/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrin alpha-5 |
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| Name: | Integrin alpha-5 |
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| Synonyms: | CD49 antigen-like family member E | CD49e antigen | FNRA | Fibrinogen receptor subunit alpha 5 beta 1 | Fibronectin receptor subunit alpha | ITA5_HUMAN | ITGA5 | Integrin alpha-5 precursor | Integrin alpha-F | VLA-5 |
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| Type: | Single-pass type I membrane protein |
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| Mol. Mass.: | 114523.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 1049 |
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| Sequence: | MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFF
GFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRL
LESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLST
DNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQ
IAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTY
GYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQ
EVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGET
QQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFG
VDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSI
GFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDK
LSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVF
GEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDY
FAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVV
SFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSI
SQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRS
SASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAV
YKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYIL
YKLGFFKRSLPYGTAMEKAQLKPPATSDA
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| BDBM141973 |
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| n/a |
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| Name | BDBM141973 |
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| Synonyms: | US8927534, 114 | US8927534, 83 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H34N4O4 |
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| Mol. Mass. | 514.6154 |
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| SMILES | Cc1ccnc(NCC2CN(C(=O)C2)c2ccc(CC(NC(=O)c3c(C)cc(C)cc3C)C(O)=O)cc2)c1 |
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| Structure | 
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