| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor XI |
|---|
| Ligand | BDBM285969 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Factor XIa Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 0.610±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Mertz, E; Edmondson, SD; So, S; Sun, W; Liu, W; Neelamkavil, SF; Gao, Y; Hruza, A; Zang, Y; Ali, A; Mal, R; He, J; Kuang, R; Wu, H; Ogawa, AK; Nolting, AF Factor XIa inhibitors US Patent US10081617 Publication Date 9/25/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor XI |
|---|
| Name: | Coagulation factor XI |
|---|
| Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 70130.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03951 |
|---|
| Residue: | 625 |
|---|
| Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
|
|
|
|---|
| BDBM285969 |
|---|
| n/a |
|---|
| Name | BDBM285969 |
|---|
| Synonyms: | US10081617, Example 116 | US10081617, Example 117 | methyl (4-{5-chloro-2-[3-(5- chloro-2-cyanophenyl)-7- hydroxy-4-methoxy-1-oxido- 6,7-dihydro-5H- cyclopenta[b]pyridin-7-yl]-1H- imidazol-4- yl}phenyl)carbamate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H21Cl2N5O5 |
|---|
| Mol. Mass. | 566.392 |
|---|
| SMILES | COC(=O)Nc1ccc(cc1)-c1nc([nH]c1Cl)C1(O)CCc2c1[n+]([O-])cc(c2OC)-c1cc(Cl)ccc1C#N |
|---|
| Structure | 
|
|---|
Search and Browse
