| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Ligand | BDBM107747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Spectra Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 22.5±n/a nM |
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| Comments | extracted |
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| Citation |  Dounay, AB; McAllister, LA; Parikh, VD; Rong, S; Verhoest, PR KAT II inhibitors US Patent US8933095 Publication Date 1/13/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Name: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Synonyms: | 2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II |
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| Type: | Enzyme |
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| Mol. Mass.: | 47353.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8N5Z0 |
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| Residue: | 425 |
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| Sequence: | MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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| BDBM107747 |
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| n/a |
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| Name | BDBM107747 |
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| Synonyms: | CHEMBL2347115 | US8933095, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H14N4O2 |
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| Mol. Mass. | 258.2759 |
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| SMILES | N[C@H]1Cc2c(cnn2Cc2ccccc2)N(O)C1=O |r| |
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| Structure | 
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