| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 12 |
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| Ligand | BDBM142616 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Resonance Energy Transfer (FRET) Assay |
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| IC50 | 89±n/a nM |
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| Citation |  Murray, PJ; Onions, ST; Williams, JG; Joly, K Respiratory formulations and compounds for use therein US Patent US8933228 Publication Date 1/13/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 12 |
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| Name: | Mitogen-activated protein kinase 12 |
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| Synonyms: | ERK6 | MAP kinase p38 gamma | MAPK12 | MK12_HUMAN | Mitogen-activated protein kinase 12 (MAPK12 p38 gamma) | Mitogen-activated protein kinase 12 (p38 gamma) | Mitogen-activated protein kinase 12 Gamma | Mitogen-activated protein kinase p38 gamma (p38 MAPKγ) | SAPK3 | p38 delta/gamma |
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| Type: | Protein |
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| Mol. Mass.: | 41938.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53778 |
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| Residue: | 367 |
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| Sequence: | MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
VSKETPL
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| BDBM142616 |
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| n/a |
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| Name | BDBM142616 |
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| Synonyms: | US8933228, 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H25Cl2N7O3 |
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| Mol. Mass. | 614.481 |
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| SMILES | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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