| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E synthase |
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| Ligand | BDBM286069 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | mPGES1 enzyme assay |
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| IC50 | 2.18±n/a nM |
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| Citation |  Li, X; He, W; Liu, X; Wang, B; Hu, Q; Jin, F; Dong, Q; Sun, P Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof US Patent US10081629 Publication Date 9/25/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E synthase |
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| Name: | Prostaglandin E synthase |
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| Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
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| Type: | Protein |
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| Mol. Mass.: | 17112.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 152 |
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| Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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| BDBM286069 |
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| n/a |
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| Name | BDBM286069 |
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| Synonyms: | 2-Chloro-N-(3-oxo-2-(4-(trifluoromethyl)phenyl)isoindolin-5-yl)-5-((2,2-dimethyl-propanoyl)amino)methyl)-benzamide | US10081629, Example 58 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25ClF3N3O3 |
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| Mol. Mass. | 543.965 |
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| SMILES | CC(C)(C)C(=O)NCc1ccc(Cl)c(c1)C(=O)Nc1ccc2CN(C(=O)c2c1)c1ccc(cc1)C(F)(F)F |
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| Structure | 
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