Reaction Details | |||
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Target | Proto-oncogene tyrosine-protein kinase ROS | ||
Ligand | BDBM144321 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 0.4±n/a nM | ||
Citation | Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent US8969336 Publication Date 3/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Proto-oncogene tyrosine-protein kinase ROS | |||
Name: | Proto-oncogene tyrosine-protein kinase ROS | ||
Synonyms: | MCF3 | Proto-oncogene c-Ros | Proto-oncogene c-Ros-1 | ROS | ROS1 | ROS1_HUMAN | Receptor tyrosine kinase c-ros oncogene 1 | Tyrosine-Protein Kinase Receptor ROS | c-Ros receptor tyrosine kinase | ||
Type: | Enzyme | ||
Mol. Mass.: | 263897.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08922 | ||
Residue: | 2347 | ||
Sequence: |
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BDBM144321 | |||
n/a | |||
Name | BDBM144321 | ||
Synonyms: | US8969336, 565 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H35N7O2 | ||
Mol. Mass. | 453.5804 | ||
SMILES | CCc1nc(C(N)=O)c(Nc2ccc(cc2)N2CCN(C)CC2)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:29.32,wD:26.28,(4.5,2.4,;4.5,.86,;3.17,.09,;1.79,.84,;.45,.07,;-.32,1.4,;.45,2.73,;-1.86,1.4,;.45,-1.47,;-.88,-2.24,;-2.22,-1.47,;-3.55,-2.24,;-4.88,-1.47,;-4.88,.07,;-3.55,.84,;-2.22,.07,;-6.22,.84,;-7.55,.07,;-8.88,.84,;-8.93,2.4,;-10.27,3.17,;-7.55,3.15,;-6.22,2.38,;1.79,-2.24,;3.12,-1.47,;4.45,-2.24,;5.79,-1.47,;7.12,-2.24,;8.45,-1.47,;8.45,.07,;9.79,.84,;7.12,.84,;5.79,.07,)| | ||
Structure |