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TargetTyrosine-protein kinase SYK
LigandBDBM144515
Substrate/Competitorn/a
Meas. Tech.Kinase Glo Luminescence Kinase Assay
IC50 0.7±n/a nM
Citation Hoffmann, MDahmann, GFiegen, DHandschuh, SKlicic, JLinz, GSchaenzle, GSchnapp, AEast, SPMazanetz, MPScott, RJWalker, E Substituted naphthyridines and their use as medicaments US Patent US8969568 Publication Date 3/3/2015
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase SYK
Name:Tyrosine-protein kinase SYK
Synonyms:KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:Enzyme
Mol. Mass.:72079.99
Organism:Homo sapiens (Human)
Description:P43405
Residue:635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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  Blast E-value cutoff:
BDBM144515
n/a
NameBDBM144515
Synonyms:US8969568, 68
TypeSmall organic molecule
Emp. Form.C19H18N6O3
Mol. Mass.378.3846
SMILESCOc1ccc(cc1OC)-c1cc2ncccc2c(NCc2n[nH]c(=O)[nH]2)n1
Structure
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