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TargetTyrosine-protein kinase SYK
LigandBDBM144504
Substrate/Competitorn/a
Meas. Tech.Kinase Glo Luminescence Kinase Assay
IC50 6.2±n/a nM
Citation Hoffmann, MDahmann, GFiegen, DHandschuh, SKlicic, JLinz, GSchaenzle, GSchnapp, AEast, SPMazanetz, MPScott, RJWalker, E Substituted naphthyridines and their use as medicaments US Patent US8969568 Publication Date 3/3/2015
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase SYK
Name:Tyrosine-protein kinase SYK
Synonyms:KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:Enzyme
Mol. Mass.:72079.99
Organism:Homo sapiens (Human)
Description:P43405
Residue:635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM144504
n/a
NameBDBM144504
Synonyms:US8969568, 103 | US8969568, 104 | US8969568, 105 | US8969568, 106 | US8969568, 109 | US8969568, 110 | US8969568, 114 | US8969568, 116 | US8969568, 57
TypeSmall organic molecule
Emp. Form.C14H15N3O2
Mol. Mass.257.2878
SMILESCc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Structure
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