Ki Summary

Reaction Details

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Target

Apoptosis regulator Bcl-2

Ligand

BDBM145145

Substrate/Competitor

n/a

Meas. Tech.

Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay

Temperature

298.15±n/a K

<0.01±n/a nM

Comments

extracted

Citation

Ding, H; Doherty, GA; Elmore, SW; Hexamer, L; Kunzer, AR; Park, C; Song, X; Souers, AJ; Sullivan, GM; Tao, Z; Wang, L; Wendt, MD; Czabotar, PE; Lessene, GL; Colman, PM Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent US8952157 Publication Date 2/10/2015

More Info.:

Get all data from this article, Assay Method

Apoptosis regulator Bcl-2

Name:

Apoptosis regulator Bcl-2

Synonyms:

Type:

Homodimer or heterodimer

Mol. Mass.:

26269.11

Organism:

Homo sapiens (Human)

Description:

P10415

Residue:

239

Sequence:

MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

BDBM145145

n/a

Name

BDBM145145

Synonyms:

US8952157, 336 | US9303025, 336

Type

Small organic molecule

Emp. Form.

C55H66ClFN8O7S

Mol. Mass.

1037.678

SMILES

CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC4CCC(CC4)N4CCN(CC4)C4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cc4cc[nH]c4cc3F)c2)=C(C1)c1ccc(Cl)cc1 |c:71,(-7.99,-9.64,;-7.17,-8.33,;-8.71,-8.39,;-7.17,-6.79,;-5.84,-6.02,;-4.5,-6.79,;-3.17,-6.02,;-3.17,-4.48,;-1.84,-3.71,;-1.84,-2.17,;-3.17,-1.4,;-4.5,-2.17,;-4.5,-3.71,;-3.17,.14,;-1.84,.91,;-1.84,2.45,;-3.17,3.22,;-3.17,4.76,;-4.5,5.53,;-1.84,5.53,;-1.84,7.07,;-.3,7.07,;-3.38,7.07,;-1.84,8.61,;-.5,9.38,;-.5,10.92,;-1.84,11.69,;-1.84,13.23,;-.5,14,;-.5,15.54,;.83,16.31,;2.17,15.54,;2.17,14,;.83,13.23,;3.5,16.31,;3.5,17.85,;4.83,18.62,;6.17,17.85,;6.17,16.31,;4.83,15.54,;7.5,18.62,;8.83,17.85,;10.17,18.62,;10.17,20.16,;8.83,20.93,;7.5,20.16,;-3.17,10.92,;-3.17,9.38,;-4.5,11.69,;-5.84,10.92,;-4.5,13.23,;-4.5,2.45,;-5.84,3.22,;-7.17,2.45,;-8.5,3.22,;-9.84,2.45,;-11.3,2.92,;-12.21,1.68,;-11.3,.43,;-9.84,.91,;-8.5,.14,;-7.17,.91,;-5.84,.14,;-4.5,.91,;-4.5,-8.33,;-5.84,-9.1,;-3.17,-9.1,;-1.84,-8.33,;-.5,-9.1,;-.5,-10.64,;.83,-11.41,;-1.84,-11.41,;-3.17,-10.64,)|

Structure