Reaction Details | |||
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Target | Sodium channel protein type 9 subunit alpha | ||
Ligand | BDBM145412 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Radioligand Binding Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1±n/a nM | ||
Comments | extracted | ||
Citation | Andrez, J; Chowdhury, S; Decker, SM; Dehnhardt, CM; Focken, T; Grimwood, ME; Hemeon, IW; Jia, Q; Li, J; Ortwine, DF; Safina, B; Sheng, T; Sun, S; Sutherlin, DP; Wilson, MS; Zenova, AY N-substituted benzamides and methods of use thereof US Patent US8952169 Publication Date 2/10/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 9 subunit alpha | |||
Name: | Sodium channel protein type 9 subunit alpha | ||
Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
Type: | Protein | ||
Mol. Mass.: | 226375.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15858 | ||
Residue: | 1988 | ||
Sequence: |
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BDBM145412 | |||
n/a | |||
Name | BDBM145412 | ||
Synonyms: | US8952169, 191 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H31FN2O4S | ||
Mol. Mass. | 462.577 | ||
SMILES | Fc1cc(OCC2C3CC4CC(C3)CC2C4)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:5:6:8:10.11.12,THB:13:14:8:10.11.12,13:11:8:14.15.6,6:14:10:8.7.12,6:7:10:14.13.15,(.14,4.04,;.14,2.5,;-1.2,1.73,;-1.2,.19,;-2.53,-.58,;-3.86,.19,;-5.2,-.58,;-6.52,.19,;-7.86,-.58,;-7.86,-2.12,;-8.69,-4.02,;-7.3,-3.37,;-7.28,-.97,;-6.09,-4.04,;-5.2,-2.12,;-6.52,-2.89,;.14,-.58,;1.47,.19,;1.47,1.73,;2.81,2.5,;2.81,4.04,;4.14,1.73,;5.47,2.5,;4.7,3.84,;6.24,3.84,;6.81,1.73,;7.2,.25,;8.69,.64,;8.29,2.13,;.14,-2.12,;-.63,-3.45,;.91,-3.45,)| | ||
Structure |