Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase pim-2

Ligand

BDBM149691

Substrate/Competitor

n/a

Meas. Tech.

Kinase Inhibition Assay

7.5±n/a

IC50

7±n/a nM

Comments

extracted

Citation

Caldarelli, M; Angiolini, M; Beria, I; Brasca, MG; Casuscelli, F; D'Alessio, R; Lombardi Borgia, A Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors US Patent US8975267 Publication Date 3/10/2015

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase pim-2

Name:

Serine/threonine-protein kinase pim-2

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

34185.93

Organism:

Homo sapiens (Human)

Description:

Q9P1W9

Residue:

311

Sequence:

MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP

BDBM149691

n/a

Name

BDBM149691

Synonyms:

US8975267, 33

Type

Small organic molecule

Emp. Form.

C18H23N5OS

Mol. Mass.

357.473

SMILES

CSc1ncc2CCc3c(cn([C@@H]4CC[C@H](N)CC4)c3-c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)|

Structure