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TargetCoagulation factor IX
LigandBDBM150295
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH8±n/a
Temperature298.15±n/a K
IC50 13±n/a nM
Commentsextracted
Citation Chackalamannil, SChan, TChelliah, MVClasby, MCDwyer, MGreenlee, WJHirabayashi, TNeelamkavil, SNishida, HSaitoh, FShah, UXia, Y Morpholinone compounds as factor IXA inhibitors US Patent US8987242 Publication Date 3/24/2015
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor IX
Name:Coagulation factor IX
Synonyms:Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:Enzyme
Mol. Mass.:51768.83
Organism:Homo sapiens (Human)
Description:P00740
Residue:461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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  Blast E-value cutoff:
BDBM150295
n/a
NameBDBM150295
Synonyms:US8987242, aa144
TypeSmall organic molecule
Emp. Form.C25H26FN5O6
Mol. Mass.511.5022
SMILESOC([C@H]1OCCN(C1=O)c1ccc(F)c(c1)C(=O)N1CCOCC1)C(=O)Nc1ccc2C(=N)NCc2c1
Structure
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