| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hepatic triacylglycerol lipase |
|---|
| Ligand | BDBM151496 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay |
|---|
| pH | 8±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 1.5±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Finlay, H; Jiang, J; Kim, S; Parkhurst, B; Qiao, JX; Wang, TC; Pi, Z; Tora, GO; Lloyd, J; Johnson, JA Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase US Patent US8987314 Publication Date 3/24/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hepatic triacylglycerol lipase |
|---|
| Name: | Hepatic triacylglycerol lipase |
|---|
| Synonyms: | HL | HTGL | Hepatic Lipase (HL) | Hepatic lipase | Hepatic triacylglycerol lipase | LIPC | LIPC_HUMAN | Lipase member C |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55938.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11150 |
|---|
| Residue: | 499 |
|---|
| Sequence: | MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQ
GCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLV
DWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSS
IGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGH
YDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAY
PCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQF
INQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKW
ENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQ
EKIFVKCEIKSKTSKRKIR
|
|
|
|---|
| BDBM151496 |
|---|
| n/a |
|---|
| Name | BDBM151496 |
|---|
| Synonyms: | US8987314, B307 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19F4N3O5S3 |
|---|
| Mol. Mass. | 553.571 |
|---|
| SMILES | NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccccc1F)S(=O)(=O)CCC(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
