| Reaction Details |
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 | Report a problem with these data |
| Target | Menin |
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| Ligand | BDBM152245 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | NMR Spectroscopy Assay |
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| IC50 | 1300±n/a nM |
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| Citation |  Grembecka, J; Cierpicki, T; Hess, J Compositions and methods for treatment of leukemia US Patent US8993552 Publication Date 3/31/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Menin |
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| Name: | Menin |
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| Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 |
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| Type: | Protein |
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| Mol. Mass.: | 68022.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00255 |
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| Residue: | 615 |
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| Sequence: | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHL
ALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKME
VAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGR
PDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCR
EDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLR
FYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEA
REGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTA
QVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTP
SDYTLSFLKRQRKGL
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| BDBM152245 |
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| n/a |
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| Name | BDBM152245 |
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| Synonyms: | US8993552, 80 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N4S |
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| Mol. Mass. | 352.496 |
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| SMILES | CCc1cc2c(NC3CCN(Cc4ccccc4)CC3)ncnc2s1 |
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| Structure | 
|
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