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TargetProteinase-activated receptor 4
LigandBDBM286464
Substrate/Competitorn/a
Meas. Tech.FLIPR Assay
Temperature298.15±n/a K
IC50 0.390±n/a nM
Commentsextracted
Citation Martel, ATremblay, FMarinier, APriestley, ESPosy, SLLawrence, RMMiller, MM Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US9518064 Publication Date 12/13/2016
More Info.:Get all data from this article,  Assay Method
 
Proteinase-activated receptor 4
Name:Proteinase-activated receptor 4
Synonyms:Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:Protein
Mol. Mass.:41145.16
Organism:Homo sapiens (Human)
Description:Q96RI0
Residue:385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
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  Blast E-value cutoff:
BDBM286464
n/a
NameBDBM286464
Synonyms:6-(4-((3-Fluoro-5-(2-methoxypyrimidin-5-yl)benzyl)oxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole | US9518064, Example 83
TypeSmall organic molecule
Emp. Form.C26H20FN5O5S
Mol. Mass.533.531
SMILESCOc1nn2cc(nc2s1)-c1cc2c(OCc3cc(F)cc(c3)-c3cnc(OC)nc3)cc(OC)cc2o1
Structure
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