| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 4 |
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| Ligand | BDBM286477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLIPR Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.230±n/a nM |
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| Comments | extracted |
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| Citation |  Martel, A; Tremblay, F; Marinier, A; Priestley, ES; Posy, SL; Lawrence, RM; Miller, MM Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US9518064 Publication Date 12/13/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 4 |
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| Name: | Proteinase-activated receptor 4 |
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| Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
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| Type: | Protein |
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| Mol. Mass.: | 41145.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96RI0 |
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| Residue: | 385 |
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| Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
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| BDBM286477 |
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| n/a |
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| Name | BDBM286477 |
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| Synonyms: | 4-(6-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)pyridin-2-yl)-N,N-dimethylbenzamide | US9518064, Example 96 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25N5O5S |
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| Mol. Mass. | 555.604 |
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| SMILES | COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(n3)-c3ccc(cc3)C(=O)N(C)C)cc(OC)cc2o1 |
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| Structure | 
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