| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
|---|
| Ligand | BDBM7459 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | DXR Inhibition Assay |
|---|
| IC50 | 3.4e+3±n/a nM |
|---|
| Citation |  Tritsch, D; Zinglé, C; Rohmer, M; Grosdemange-Billiard, C Flavonoids: true or promiscuous inhibitors of enzyme? The case of deoxyxylulose phosphate reductoisomerase. Bioorg Chem59:140-4 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
|---|
| Name: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
|---|
| Synonyms: | 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXP) | 1-Deoxyxylulose 5-phosphate reductoisomerase (DXR) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) | 2-C-methyl-D-erythritol 4-phosphate synthase | DXP reductoisomerase | DXR_ECOLI | dxr | ispC | yaeM |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43384.52 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | P45568 |
|---|
| Residue: | 398 |
|---|
| Sequence: | MKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEA
SAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTI
LLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVS
ILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFC
KLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN
LSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS
|
|
|
|---|
| BDBM7459 |
|---|
| n/a |
|---|
| Name | BDBM7459 |
|---|
| Synonyms: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one | CHEMBL151 | Luteolin (27) | Luteolin (4) | acs.jmedchem.1c00409_ST.600 | cid_5280445 | luteolin | med.21724, Compound 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H10O6 |
|---|
| Mol. Mass. | 286.2363 |
|---|
| SMILES | Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
