| Reaction Details |
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 | Report a problem with these data |
| Target | Neuraminidase |
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| Ligand | BDBM4997 |
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| Substrate/Competitor | BDBM4702 |
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| Meas. Tech. | Neuraminidase Inhibition Assay |
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| IC50 | 1±n/a nM |
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| Citation |  Kim, CU; Lew, W; Williams, MA; Wu, H; Zhang, L; Chen, X; Escarpe, PA; Mendel, DB; Laver, WG; Stevens, RC Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors. J Med Chem41:2451-60 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Neuraminidase |
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| Name: | Neuraminidase |
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| Synonyms: | Influenza A Virus Neuraminidase | NA | NRAM_I34A1 | Neuraminidase | Neuraminidase A |
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| Type: | Enzyme |
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| Mol. Mass.: | 50124.14 |
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| Organism: | Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(H1N1)) |
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| Description: | P03468 |
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| Residue: | 454 |
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| Sequence: | MNPNQKIITIGSICLVVGLISLILQIGNIISIWISHSIQTGSQNHTGICNQNIITYKNST
WVKDTTSVILTGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLT
QGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGI
SGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECACVNGSCFTIMTDGPSDGLASYKI
FKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIG
YICSGVFGDNPRPEDGTGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSHSSRHGFEMIW
DPNGWTETDSKFSVRQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKEKT
IWTSASSISFCGVNSDTVDWSWPDGAELPFSIDK
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| BDBM4997 |
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| BDBM4702 |
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| Name | BDBM4997 |
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| Synonyms: | (3R,4R,5S)-4-Acetamido-5-amino-3-[(3S)-decyloxy]-1-cyclohexene-1-carboxylic Acid | (3R,4R,5S)-5-amino-3-[(3S)-decan-3-yloxy]-4-acetamidocyclohex-1-ene-1-carboxylic acid | Carbocyclic Analogue 47 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H34N2O4 |
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| Mol. Mass. | 354.4843 |
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| SMILES | CCCCCCC[C@H](CC)O[C@@H]1C=C(C[C@H](N)[C@H]1NC(C)=O)C(O)=O |r,c:12| |
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| Structure | 
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