| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM152725 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC8 Fluorimetric Assay |
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| pH | 8.2±n/a |
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| IC50 | 2.6e+2± 2e+1 nM |
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| Comments | extracted |
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| Citation |  Decroos, C; Christianson, DW Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase. Biochemistry54:4692-703 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM152725 |
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| n/a |
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| Name | BDBM152725 |
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| Synonyms: | (3-azaniumylpropyl)(7,7,7-trifluoro-6-oxoheptyl)azanium (1) |
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| Type | Small organic molecule |
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| Emp. Form. | C10H21F3N2O |
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| Mol. Mass. | 242.2807 |
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| SMILES | [NH3+]CCC[NH2+]CCCCCC(=O)C(F)(F)F |
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| Structure | 
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