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TargetNeuraminidase A
LigandBDBM5024
Substrate/CompetitorBDBM4702
Meas. Tech.Neuraminidase Inhibition Assay
pH6.5±n/a
Temperature310.15±n/a K
IC50<1±n/a nM
Citation Chand PKotian PLDehghani AEl-Kattan YLin THHutchison TLBabu YSBantia SElliott AJMontgomery JA Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity. J Med Chem 44:4379-92 (2001) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Neuraminidase A
Name:Neuraminidase A
Synonyms:Influenza A Virus Neuraminidase
Type:Enzyme
Mol. Mass.:52000.86
Organism:Influenza A virus (A/Singapore/1/57(H2N2))
Description:Q6XUE4
Residue:469
Sequence:
MNPNQKIITIGSVSLTIATVCFLMQIAILATTVTLHFKQHECDSPASNQVMPCEPIIIER
NITEIVYLNNTTIEKEICPEVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREP
YVSCDPGKCYQFALGQGTTLDNKHSNGTIHDRIPHRTLLMNELGVPFHLGTKQVCVAWSS
SSCHDGKAWLHVCVTGDDRNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVV
MTDGSASGRADTRILFIKEGKIVHISPLSGSAQHIEECSCYPRYPDVRCICRDNWKGSNR
PVIDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRDPNNERGNPGVKGWAFDNGDDV
WMGRTINKDSRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINR
CFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI
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  Blast E-value cutoff:
BDBM5024
BDBM4702
NameBDBM5024
Synonyms:(-)-(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-{[amino(imino)methyl]amino}-2-hydroxycyclopentanecarboxylic Acid | (1S,2S,3R,4R)-4-carbamimidamido-3-[(1S)-1-acetamido-2-ethylbutyl]-2-hydroxycyclopentane-1-carboxylic acid | BCX-1812
TypeSmall organic molecule
Emp. Form.C15H28N4O4
Mol. Mass.328.4072
SMILES[H][C@](NC(C)=O)(C(CC)CC)[C@@H]1[C@H](O)[C@H](C[C@H]1N=C(N)N)C(O)=O |r|
Structure
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