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TargetNeuraminidase B
LigandBDBM5025
Substrate/CompetitorBDBM4702
Meas. Tech.Neuraminidase Inhibition Assay
pH6.5±n/a
Temperature310.15±n/a K
IC50 5±n/a nM
Citation Chand PKotian PLDehghani AEl-Kattan YLin THHutchison TLBabu YSBantia SElliott AJMontgomery JA Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity. J Med Chem 44:4379-92 (2001) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Neuraminidase B
Name:Neuraminidase B
Synonyms:Influenza B Virus Neuraminidase
Type:Enzyme
Mol. Mass.:37412.70
Organism:Influenza B virus (B/Victoria/70)
Description:Q9QMU3
Residue:346
Sequence:
DRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTQTRGKLCPNCLNC
TDLDVALGRPNCMGTIPSAKASILHEVKPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLS
PRNVINAEAAPGGPYIVGTSGSCPNVTNGKGFFATMAWAVPKKNNKTATNPLTVEVPYIC
TKGEDQITVWGFHSDNEAQMVTLYGDSKPQKFTSSANGVTTHYVSQIGGFPNQTEDEGLP
QSGRIVVDYMVQKPGKTGTIVYQRGVLLPQKVWCASGRSKVIKGSLPLIGEADCLHERYG
GLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKYRPPAKLLKER
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  Blast E-value cutoff:
BDBM5025
BDBM4702
NameBDBM5025
Synonyms:Oseltamivir | ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
TypeSmall organic molecule
Emp. Form.C16H28N2O4
Mol. Mass.312.4045
SMILES[H][C@@]1(OC(CC)CC)C=C(C[C@H](N)[C@H]1NC(C)=O)C(=O)OCC |r,c:8|
Structure
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