| Reaction Details |
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 | Report a problem with these data |
| Target | Decaprenyl diphosphate synthase |
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| Ligand | BDBM25284 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DPPS Inhibition (trans FPP based) Assay |
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| pH | 7.5±n/a |
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| IC50 | 8.2e+3±n/a nM |
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| Comments | extracted |
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| Citation |  Kim, MO; Feng, X; Feixas, F; Zhu, W; Lindert, S; Bogue, S; Sinko, W; de Oliveira, C; Rao, G; Oldfield, E; McCammon, JA A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery. Chem Biol Drug Des85:756-69 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Decaprenyl diphosphate synthase |
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| Name: | Decaprenyl diphosphate synthase |
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| Synonyms: | DPDS_MYCTO | cis-Decaprenyl diphosphate synthase (cis-DPPS) | uppS |
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| Type: | Protein |
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| Mol. Mass.: | 33800.02 |
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| Organism: | Mycobacterium tuberculosis H37Rv |
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| Description: | n/a |
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| Residue: | 296 |
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| Sequence: | MARDARKRTSSNFPQLPPAPDDYPTFPDTSTWPVVFPELPAAPYGGPCRPPQHTSKAAAP
RIPADRLPNHVAIVMDGNGRWATQRGLARTEGHKMGEAVVIDIACGAIELGIKWLSLYAF
STENWKRSPEEVRFLMGFNRDVVRRRRDTLKKLGVRIRWVGSRPRLWRSVINELAVAEEM
TKSNDVITINYCVNYGGRTEITEATREIAREVAAGRLNPERITESTIARHLQRPDIPDVD
LFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACEEYASRTRRFGSA
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| BDBM25284 |
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| n/a |
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| Name | BDBM25284 |
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| Synonyms: | (1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phenyl]phenyl}-1-phosphonoethyl)phosphonic acid | BPH-675 | bisphosphonate, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23NO9P2S |
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| Mol. Mass. | 563.453 |
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| SMILES | OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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