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TargetTuberculosinyl adenosine transferase
LigandBDBM25288
Substrate/Competitorn/a
Meas. Tech.Rv3378c Inhibition Assay
IC50 2.1e+2±n/a nM
Citation Kim, MOFeng, XFeixas, FZhu, WLindert, SBogue, SSinko, Wde Oliveira, CRao, GOldfield, EMcCammon, JA A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery. Chem Biol Drug Des85:756-69 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tuberculosinyl adenosine transferase
Name:Tuberculosinyl adenosine transferase
Synonyms:Diterpene synthase | TUBAT_MYCTO | Tuberculosinyl adenosine synthase (Rv3378c)
Type:Protein
Mol. Mass.:34026.59
Organism:Mycobacterium tuberculosis H37Rv
Description:n/a
Residue:296
Sequence:
MNLVSEKEFLDLPLVSVAEIVRCRGPKVSVFPFDGTRRWFHLECNPQYDDYQQAALRQSI
RILKMLFEHGIETVISPIFSDDLLDRGDRYIVQALEGMALLANDEEILSFYKEHEVHVLF
YGDYKKRLPSTAQGAAVVKSFDDLTISTSSNTEHRLCFGVFGNDAAESVAQFSISWNETH
GKPPTRREIIEGYYGEYVDKADMFIGFGRFSTFDFPLLSSGKTSLYFTVAPSYYMTETTL
RRILYDHIYLRHFRPKPDYSAMSADQLNVLRNRYRAQPDRVFGVGCVHDGIWFAEG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM25288
n/a
NameBDBM25288
Synonyms:BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(13),2,4,6,9,11-hexaen-6-yl}phenyl)-1-phosphonoethyl]phosphonic acid | bisphosphonate, 8
TypeSmall organic molecule
Emp. Form.C20H18O8P2
Mol. Mass.448.2996
SMILESOC(Cc1cccc(c1)-c1cccc2c1oc1ccccc21)(P(O)(O)=O)P(O)(O)=O
Structure
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