| Reaction Details |
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 | Report a problem with these data |
| Target | Short-chain Z-isoprenyl diphosphate synthase |
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| Ligand | BDBM153318 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radiometric Assay |
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| IC50 | 4.8e+3±n/a nM |
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| Citation |  Kim, MO; Feng, X; Feixas, F; Zhu, W; Lindert, S; Bogue, S; Sinko, W; de Oliveira, C; Rao, G; Oldfield, E; McCammon, JA A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery. Chem Biol Drug Des85:756-69 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Short-chain Z-isoprenyl diphosphate synthase |
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| Name: | Short-chain Z-isoprenyl diphosphate synthase |
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| Synonyms: | ZFPP_MYCBO | cis-Farnesyl diphosphate synthase (cis-FPPS) |
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| Type: | Protein |
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| Mol. Mass.: | 29475.52 |
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| Organism: | Mycobacterium tuberculosis H37Rv |
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| Description: | Q7U0P8 |
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| Residue: | 262 |
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| Sequence: | MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRM
GAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSV
RTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGA
TAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
FRHVDFLRALRDYSARHRRYGR
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| BDBM153318 |
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| n/a |
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| Name | BDBM153318 |
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| Synonyms: | BPH-1417 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N6 |
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| Mol. Mass. | 394.4717 |
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| SMILES | C1CN=C(N1)c1ccc2cc(\C=C\c3cc4ccc(cc4[nH]3)C3=NCCN3)[nH]c2c1 |c:2,t:25| |
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| Structure | 
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