Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetClass I phosphodiesterase B1 (TbrPDEB1)
LigandBDBM153396
Substrate/Competitorn/a
Meas. Tech.TbrPDEB1 Enzyme Assay
pH7.4±n/a
IC50 9e+3± 6e+2 nM
Commentsextracted
Citation Ochiana SOBland NDSettimo LCampbell RKPollastri MP Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei. Chem Biol Drug Des 85:549-64 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Class I phosphodiesterase B1 (TbrPDEB1)
Name:Class I phosphodiesterase B1 (TbrPDEB1)
Synonyms:Class 1 phosphodiesterase PDEB1 | PDEB1
Type:Protein
Mol. Mass.:103683.20
Organism:Trypanosoma brucei
Description:n/a
Residue:930
Sequence:
MFMNKPFGSKRCEPFHESEHLCEAFAITEAILARYQRGKRSFTSSEKSGLAALIKRIPYD
ILVEVLDQSGFTPTSNATPPVDYLAMMEHTMTHGASITHALQYLNDLMTKCTGCPGIRTY
YHNPNDDVLADPVHDTAALIDETTAVGKSVVTKQYLNIAGAHYIPLIHGDIVVGCVEVPR
FSGNLEKLPSFPSLIRAVTCTAHKFIEEARINWNREKAEAMLQMATRLARDNLDETVLAS
SIMNTVKSLTESARCSLFLVKDDKLEAHFEDGNVVSIPKGTGIVGYVAQTGETVNIVDAY
ADDRFNREVDKATGYRTKTILCMPVMYEGTIVAVTQLINKLDLTTESGLRLPRVFGKRDE
ELFQTFSMFAGASLRNCRINDRLLKEKKKSDVILDVVTVLSNTDIRDVDGIVRHALHGAK
KLLNADRSTLFLVDKERNELCSRMADSVAGKEIRFPCGQGIAGTVAASGVGENIQDAYQD
PRFNREVDKQLGYRTQTILCEPIILNGEILAVVQLVNKLDTSGEVTVFTEDDRDTFRVFS
LFAGISINNSHLLEFAVKAGREVMELNEHRATLFNKNVPSRAVKRVTAITKVEREAVLVC
ELPSFDVTDVEFDLFRARESTDKPLDVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCR
KKYRNVPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLITALVHDLDHMGLNNSF
YLKTESPLGILSSASGNTSVLEVHHCNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCV
LATDMAKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNVTKPFDISRQWAMAV
TEEFYRQGDMEKERGVEVLPMFDRSKNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWT
VDRIKSNRAQWERVLETRLSTSSGNNSSTR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM153396
n/a
NameBDBM153396
Synonyms:4-((3-Methoxyphenyl)amino)-8-methyl-6-(1H-pyrazol-4-yl)quinoline-3-carboxamide (17j)
TypeSmall organic molecule
Emp. Form.C21H19N5O2
Mol. Mass.373.4079
SMILESCOc1cccc(Nc2c(cnc3c(C)cc(cc23)-c2cn[nH]c2)C(N)=O)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: