| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
|---|
| Ligand | BDBM50359396 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 6700±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Samadi, A; Marco Contelles, JL; Bolea Tomás, I; Luque Garriga, FJ; Unzeta López, M Derivatives of propargylamine having neuroprotective capacity for the treatment of Alzheimer's and Parkinson's diseases US Patent US8999994 Publication Date 4/7/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Amine oxidase [flavin-containing] A |
|---|
| Name: | Amine oxidase [flavin-containing] A |
|---|
| Synonyms: | AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 59515.21 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 526 |
|---|
| Sequence: | MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV
KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA
YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI
NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL
SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM
GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR
QAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD
VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
|
|
|
|---|
| BDBM50359396 |
|---|
| n/a |
|---|
| Name | BDBM50359396 |
|---|
| Synonyms: | CHEMBL1929420 | US8999994, 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H35N3O |
|---|
| Mol. Mass. | 429.597 |
|---|
| SMILES | CN(CC#C)Cc1cc2cc(OCCC3CCN(Cc4ccccc4)CC3)ccc2n1C |
|---|
| Structure | 
|
|---|
Search and Browse
