| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
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| Ligand | BDBM153703 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | KinEASE Assay |
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| IC50 | 10± 4 nM |
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| Citation |  Fang, Z; Simard, JR; Plenker, D; Nguyen, HD; Phan, T; Wolle, P; Baumeister, S; Rauh, D Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors. ACS Chem Biol10:279-88 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
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| Name: | RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
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| Synonyms: | AKT1 | AKT1_HUMAN | PKB | Protein kinase B (Akt1 E49C, C296S, C310S and C344S ) | RAC |
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| Type: | Protein |
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| Mol. Mass.: | 55608.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human Akt1 containing mutations E49C, C296S, C310S and C344S |
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| Residue: | 480 |
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| Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRCAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLSKEGI
KDGATMKTFSGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMSGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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| BDBM153703 |
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| n/a |
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| Name | BDBM153703 |
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| Synonyms: | 2-(4-((4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)phenyl)-3-phenyl-1,6-naphthyridin-5(6H)-one (7b) |
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| Type | Small organic molecule |
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| Emp. Form. | C33H28ClN5O2 |
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| Mol. Mass. | 562.061 |
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| SMILES | Clc1ccc2n(C3CCN(Cc4ccc(cc4)-c4nc5cc[nH]c(=O)c5cc4-c4ccccc4)CC3)c(=O)[nH]c2c1 |
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| Structure | 
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