| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
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| Ligand | BDBM50237622 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | KinEASE Assay |
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| IC50 | 29± 9 nM |
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| Citation |  Fang, Z; Simard, JR; Plenker, D; Nguyen, HD; Phan, T; Wolle, P; Baumeister, S; Rauh, D Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors. ACS Chem Biol10:279-88 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
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| Name: | RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
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| Synonyms: | AKT1 | AKT1_HUMAN | PKB | Protein kinase B (Akt1 E49C, C296S, C310S and C344S ) | RAC |
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| Type: | Protein |
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| Mol. Mass.: | 55608.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human Akt1 containing mutations E49C, C296S, C310S and C344S |
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| Residue: | 480 |
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| Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRCAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLSKEGI
KDGATMKTFSGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMSGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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| BDBM50237622 |
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| n/a |
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| Name | BDBM50237622 |
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| Synonyms: | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin- | 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine | CCT128930 | CHEMBL263664 | US8796293, 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20ClN5 |
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| Mol. Mass. | 341.838 |
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| SMILES | NC1(Cc2ccc(Cl)cc2)CCN(CC1)c1ncnc2[nH]ccc12 |
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| Structure | 
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