Reaction Details |
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Target | Phospholipase |
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Ligand | BDBM20608 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Exogenous PldA Assay |
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pH | 7.5±n/a |
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IC50 | 18000±270 nM |
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Comments | extracted |
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Citation | Scott, SA; Spencer, CT; O'Reilly, MC; Brown, KA; Lavieri, RR; Cho, CH; Jung, DI; Larock, RC; Brown, HA; Lindsley, CW Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes. ACS Chem Biol10:421-32 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phospholipase |
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Name: | Phospholipase |
Synonyms: | Phospholipase D (PldA) |
Type: | Protein |
Mol. Mass.: | 122309.70 |
Organism: | Pseudomonas aeruginosa (g-Proteobacteria) |
Description: | A0A0C6EPQ5 |
Residue: | 1099 |
Sequence: | MLQKKPYNGLHEKELNQINQQDGSPCVAISAPGCFIKGSNLFSEKRAGNRVRFFTTGRDY
FSDLASALDSASSSIFITGWQVNYDVLLDGRRSLWQCLRQALERSPALKVYVMPWLSPSG
SLGTYDFETMLAVFQLNAGLEGGARAFCTPAIQQSDMQGLGVAFSHHQKSVVIDNRIGYV
GGIDLAYGRRDDNDFSLDASGRRGNDAYNPGLPHLGWMAEDEHVSSMGLMMATLFDLSRP
LASLTLHAPTLRLSPFPHIAASDEPLLSIPLAPSRARALNGGAYLSDLFRSPMLPSLQWL
GRAYNSSKEGLDEGFERLDALRRQMVASSIRAIANLIADNLDALPIEPELERRLRAWLEE
LRTAALNLPEALRIKSLLLINQWMSETELGQVLTLISGKGFEDIPQNLSGKAGELAGSLF
WTLHRLLQARAGGHQQPYRYLDEAPQPLASPDNARLAADQPRMPWQDVHCRIEGPSVYDL
ARNFIDRWNGQQAYLAKTPALQDTALVRSALEAVMKWLNSLAAAAGLENYLDEKRNLRLE
LDPPTPCWINAPEQLPQEPEVRRGGMTVQVLRSAAARMLEQEQAGRLGAGVNLPLQVGVS
TEGVQSNCKDAMLLAISGAQQFIYIENQFFQSEFGKEGEVFKDLPLSGPMASLRDVGSLR
RDFVVRIRLEEALEQRDLWLLDWAEVEKIAQEPGTEARQFLKSMLAMWGVNAQGWLTHKL
GEAQHGLLNEIGEALARRIERAIQREHPFHVYLVLPVHPEGALNVPNIMHQVHLTQQSLV
FGEQSLVKRIQRQMALKALEGKSDPAQAREIIERKDARGRPVYEQQDWSRYLTLLNLRTW
AVLGGRVVTEQIYVHSKLLIADDRVAILGSANINDRSLQGERDSELAVMVRDSEPLTVRL
DGKNDAIVGKAIHQLRVNLWKKHFGLSQGPGGFVKPASELSAYLSIPAAQEAWEAIQTLA
KENTRAYERTFNFIPQNISQTQLQLTPEPPKGFEDGFPASIWPTWAYRKPGELRAGGQLM
EPMPYQEIFWRSSNLTSVKTFPPPNGVSGFITALPTSWTRGERNDSGLNLSILAHQDSRS
LPTQVAMNGDSSAQGKHRT
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BDBM20608 |
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n/a |
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Name | BDBM20608 |
Synonyms: | 4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol | AFIMOXIFENE | CHEMBL489 | [3H]4-OHT | cid_449459 |
Type | Small organic molecule |
Emp. Form. | C26H29NO2 |
Mol. Mass. | 387.514 |
SMILES | CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 |
Structure |
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