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TargetCyclin-dependent protein kinase 2 variant (CDK2 C118L)
LigandBDBM154576
Substrate/Competitorn/a
Meas. Tech.ITC Assay
pH7.5±0
Temperature1107.6±0 K
Kd 18.6±2.9 nM
Citation Alexander LTM÷bitz HDrueckes PSavitsky PFedorov OElkins JMDeane CMCowan-Jacob SWKnapp S Type II Inhibitors Targeting CDK2. ACS Chem Biol 10:2116-25 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent protein kinase 2 variant (CDK2 C118L)
Name:Cyclin-dependent protein kinase 2 variant (CDK2 C118L)
Synonyms:n/a
Type:Protein
Mol. Mass.:33835.03
Organism:Homo sapiens (Human)
Description:CDK2 mutant (C118L)
Residue:297
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRDTETEGVPSTAIREISLLKELNHP
NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFLHSH
RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS
TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP
KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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  Blast E-value cutoff:
BDBM154576
n/a
NameBDBM154576
Synonyms:K03861 (1)
TypeSmall organic molecule
Emp. Form.C24H26F3N7O2
Mol. Mass.501.5041
SMILESCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Structure
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