Reaction Details |
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Target | Cyclin-dependent kinase 2 [C118L,A144C] |
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Ligand | BDBM154576 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ITC Assay |
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pH | 7.5±0 |
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Temperature | 1107.6±0 K |
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Kd | 9.7±0.8 nM |
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Citation | Alexander, LT; Möbitz, H; Drueckes, P; Savitsky, P; Fedorov, O; Elkins, JM; Deane, CM; Cowan-Jacob, SW; Knapp, S Type II Inhibitors Targeting CDK2. ACS Chem Biol10:2116-25 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2 [C118L,A144C] |
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Name: | Cyclin-dependent kinase 2 [C118L,A144C] |
Synonyms: | CDK2 | CDK2_HUMAN | CDKN2 | Cyclin-dependent protein kinase 2 variant (CDK2 C118L/A144C) |
Type: | Protein |
Mol. Mass.: | 33980.25 |
Organism: | Homo sapiens (Human) |
Description: | CDK2 mutant (C118L/A144C) |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFLHS
HRVLHRDLKPQNLLINTEGAIKLCDFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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BDBM154576 |
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n/a |
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Name | BDBM154576 |
Synonyms: | K03861 (1) |
Type | Small organic molecule |
Emp. Form. | C24H26F3N7O2 |
Mol. Mass. | 501.5041 |
SMILES | CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1 |
Structure |
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