| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 [F80T] |
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| Ligand | BDBM154577 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | EMSA |
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| Temperature | 576.3±0 K |
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| IC50 | 7.1e+3±n/a nM |
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| Citation |  Alexander, LT; Möbitz, H; Drueckes, P; Savitsky, P; Fedorov, O; Elkins, JM; Deane, CM; Cowan-Jacob, SW; Knapp, S Type II Inhibitors Targeting CDK2. ACS Chem Biol10:2116-25 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 [F80T] |
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| Name: | Cyclin-dependent kinase 2 [F80T] |
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| Synonyms: | CDK2 | CDK2_HUMAN | CDKN2 | Cyclin-dependent protein kinase 2 (CDK2 F80T) |
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| Type: | Protein |
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| Mol. Mass.: | 33892.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941[F80T] |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVTEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM154577 |
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| n/a |
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| Name | BDBM154577 |
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| Synonyms: | K03859 (2) |
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| Type | Small organic molecule |
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| Emp. Form. | C30H29F3N6O3 |
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| Mol. Mass. | 578.5849 |
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| SMILES | CN1CCN(Cc2ccc(NC(=O)c3cccc4cc(Oc5cc(NC(C)=O)ncn5)ccc34)cc2C(F)(F)F)CC1 |
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| Structure | 
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