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TargetCyclin-dependent protein kinase 2 variant (CDK2 A144C)
LigandBDBM154577
Substrate/Competitorn/a
Meas. Tech.EMSA
Temperature576.3±0 K
IC50>1.0e+4± 0 nM
Citation Alexander LTM÷bitz HDrueckes PSavitsky PFedorov OElkins JMDeane CMCowan-Jacob SWKnapp S Type II Inhibitors Targeting CDK2. ACS Chem Biol 10:2116-25 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent protein kinase 2 variant (CDK2 A144C)
Name:Cyclin-dependent protein kinase 2 variant (CDK2 A144C)
Synonyms:n/a
Type:Protein
Mol. Mass.:33857.08
Organism:Homo sapiens (Human)
Description:CDK2 mutant (A144C)
Residue:297
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRDTETEGVPSTAIREISLLKELNHP
NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH
RVLHRDLKPQNLLINTEGAIKLCDFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS
TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP
KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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  Blast E-value cutoff:
BDBM154577
n/a
NameBDBM154577
Synonyms:K03859 (2)
TypeSmall organic molecule
Emp. Form.C30H29F3N6O3
Mol. Mass.578.5849
SMILESCN1CCN(Cc2ccc(NC(=O)c3cccc4cc(Oc5cc(NC(C)=O)ncn5)ccc34)cc2C(F)(F)F)CC1
Structure
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