Reaction Details |
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Target | Mitogen-activated protein kinase 1 |
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Ligand | BDBM154599 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Coupled ERK2 (cERK) Assay |
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pH | 7.2±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 2.9±n/a nM |
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Comments | extracted |
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Citation | Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Heterocyclic compounds as ERK inhibitors US Patent US8999957 Publication Date 4/7/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 1 |
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Name: | Mitogen-activated protein kinase 1 |
Synonyms: | ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK |
Type: | Protein |
Mol. Mass.: | 41278.65 |
Organism: | Mus musculus (Mouse) |
Description: | P63085 |
Residue: | 358 |
Sequence: | MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM154599 |
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n/a |
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Name | BDBM154599 |
Synonyms: | US8999957, Column 153, Compound 4 | US8999957, Table 1, Compound 6 |
Type | Small organic molecule |
Emp. Form. | C25H25N5O |
Mol. Mass. | 411.4989 |
SMILES | O=C(N[C@@H]1CCCN(Cc2ccccc2)C1)c1ccc2[nH]nc(-c3ccncc3)c2c1 |r| |
Structure |
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