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TargetMitogen-activated protein kinase 1
LigandBDBM154613
Substrate/Competitorn/a
Meas. Tech.IMAP-FP Assay
IC50 1.1±n/a nM
Citation Deng, YZhu, LShipps, Jr., GWLo, SSun, BHuang, XBienstock, CCooper, ABGao, XYao, XZhu, HYKelly, JMBoga, SBAlhassan, ATagat, JRMansoor, UFWilson, KJO'Boyle, BMDaniels, MHSchell, ASiliphaivanh, PFischer, C Heterocyclic compounds as ERK inhibitors US Patent US8999957 Publication Date 4/7/2015
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK
Type:Protein
Mol. Mass.:41278.65
Organism:Mus musculus (Mouse)
Description:P63085
Residue:358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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  Blast E-value cutoff:
BDBM154613
n/a
NameBDBM154613
Synonyms:US8999957, Column 165-167, Compound 2
TypeSmall organic molecule
Emp. Form.C32H35FN6O4
Mol. Mass.586.6565
SMILESCOc1cccc(F)c1CN1C[C@@H](CC[C@H]1C(=O)N1CC(C)(O)C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
Structure
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