Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMitogen-activated protein kinase 1
LigandBDBM154811
Substrate/Competitorn/a
Meas. Tech.IMAP Assay
IC50 3.2±n/a nM
Citation Deng, YZhu, LShipps, Jr., GWLo, SSun, BHuang, XBienstock, CCooper, ABGao, XYao, XZhu, HYKelly, JMBoga, SBAlhassan, ATagat, JRMansoor, UFWilson, KJO'Boyle, BMDaniels, MHSchell, ASiliphaivanh, PFischer, C Heterocyclic compounds as ERK inhibitors US Patent US8999957 Publication Date 4/7/2015
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK
Type:Protein
Mol. Mass.:41278.65
Organism:Mus musculus (Mouse)
Description:P63085
Residue:358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM154811
n/a
NameBDBM154811
Synonyms:BDBM154818 | US8999957, Table 3, Compound 83
TypeSmall organic molecule
Emp. Form.C28H29FN6O3
Mol. Mass.516.5667
SMILESCNC(=O)[C@@H]1CC[C@H](CN1Cc1c(F)cccc1OC)NC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: