Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM154931 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Assay |
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Temperature | 310.15±n/a K |
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IC50 | 57±n/a nM |
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Comments | extracted |
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Citation | Boss, C; Brotschi, C; Gatfield, J; Gude, M; Heidmann, B; Sifferlen, T; Williams, JT Proline sulfonamide derivatives as orexin receptor antagonists US Patent US9000029 Publication Date 4/7/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM154931 |
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n/a |
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Name | BDBM154931 |
Synonyms: | US9000029, 10 |
Type | Small organic molecule |
Emp. Form. | C20H24N2O5S2 |
Mol. Mass. | 436.545 |
SMILES | COc1ccc(cc1OC)S(=O)(=O)N1CCC[C@H]1C(=O)Nc1cccc(SC)c1 |
Structure |
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