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TargetOrexin/Hypocretin receptor type 1
LigandBDBM154933
Substrate/Competitorn/a
Meas. Tech.In Vitro Assay
Temperature310.15±n/a K
IC50 5±n/a nM
Commentsextracted
Citation Boss, CBrotschi, CGatfield, JGude, MHeidmann, BSifferlen, TWilliams, JT Proline sulfonamide derivatives as orexin receptor antagonists US Patent US9000029 Publication Date 4/7/2015
More Info.:Get all data from this article,  Assay Method
 
Orexin/Hypocretin receptor type 1
Name:Orexin/Hypocretin receptor type 1
Synonyms:HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:Protein
Mol. Mass.:47554.50
Organism:Homo sapiens (Human)
Description:O43613
Residue:425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM154933
n/a
NameBDBM154933
Synonyms:US9000029, 12
TypeSmall organic molecule
Emp. Form.C19H21ClN2O3S2
Mol. Mass.424.965
SMILESCSc1cccc(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc(C)c(Cl)c2)c1
Structure
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