Reaction Details | |||
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Target | Amyloid-beta precursor protein | ||
Ligand | BDBM155098 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Release Assay | ||
Temperature | 310.15±n/a K | ||
IC50 | 2±n/a nM | ||
Comments | extracted | ||
Citation | Karlstrom, S; Csjernyik, G; Swahn, B; Sandberg, L; Kolmodin, K; Soderman, P; Ohberg, L 2H-imidazol-4-amine compounds and their use as BACE inhibitors US Patent US9000182 Publication Date 4/7/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Amyloid-beta precursor protein | |||
Name: | Amyloid-beta precursor protein | ||
Synonyms: | A4 | A4_HUMAN | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid beta Protein | Amyloid beta protein (sAPPbeta) | Amyloid beta protein Abeta(1-42) | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Amyloid protein (Abeta42b) | Amyloid β-protein (Aβ42) | Beta amyloid A4 protein | Beta-APP40 | Beta-APP42 | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma Secretase | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta | beta-Amyloid Precursor Protein (APP) | ||
Type: | Single-pass type I membrane protein | ||
Mol. Mass.: | 86890.41 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P05067 | ||
Residue: | 770 | ||
Sequence: |
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BDBM155098 | |||
n/a | |||
Name | BDBM155098 | ||
Synonyms: | US9000182, 7, isomer 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H29N3O | ||
Mol. Mass. | 375.5066 | ||
SMILES | CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@]22N=C(C)C(N)=N2)C#CC2CCC2)CC1 |r,wD:5.5,2.1,13.15,c:20,t:16,(8.27,-3.04,;7.5,-1.7,;5.96,-1.7,;5.19,-.37,;3.65,-.37,;2.88,-1.7,;1.97,-2.95,;.51,-2.47,;-.83,-3.24,;-2.16,-2.47,;-2.16,-.93,;-.83,-.16,;.51,-.93,;1.97,-.46,;.72,.45,;1.2,1.91,;.43,3.24,;2.74,1.91,;3.51,3.24,;3.22,.45,;-3.49,-.16,;-4.83,.61,;-6.16,1.38,;-6.93,2.71,;-8.27,1.94,;-7.5,.61,;3.65,-3.04,;5.19,-3.04,)| | ||
Structure |