Reaction Details | |||
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Target | Amyloid-beta precursor protein | ||
Ligand | BDBM155147 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Release Assay | ||
Temperature | 310.15±n/a K | ||
IC50 | 0.9±n/a nM | ||
Comments | extracted | ||
Citation | Karlstrom, S; Soderman, P; Swahn, B; Rakos, L; Ohberg, L Cycloalkyl ether compounds and their use as BACE inhibitors US Patent US9000185 Publication Date 4/7/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Amyloid-beta precursor protein | |||
Name: | Amyloid-beta precursor protein | ||
Synonyms: | A4 | A4_HUMAN | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid beta Protein | Amyloid beta protein (sAPPbeta) | Amyloid beta protein Abeta(1-42) | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Amyloid protein (Abeta42b) | Amyloid β-protein (Aβ42) | Beta amyloid A4 protein | Beta-APP40 | Beta-APP42 | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma Secretase | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta | beta-Amyloid Precursor Protein (APP) | ||
Type: | Single-pass type I membrane protein | ||
Mol. Mass.: | 86890.41 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P05067 | ||
Residue: | 770 | ||
Sequence: |
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BDBM155147 | |||
n/a | |||
Name | BDBM155147 | ||
Synonyms: | US9000185, 4, isomer 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H29N3O2 | ||
Mol. Mass. | 367.4846 | ||
SMILES | CO[C@H]1CC[C@@]2(Cc3ccc(OCC4CC4)cc3[C@@]22N=C(C)C(N)=N2)CC1 |r,wU:18.21,wD:5.5,2.1,c:26,t:22,(7.98,-3.04,;7.21,-1.7,;5.67,-1.7,;4.9,-.37,;3.36,-.37,;2.59,-1.7,;1.69,-2.95,;.22,-2.47,;-1.11,-3.24,;-2.44,-2.47,;-2.44,-.93,;-3.78,-.16,;-5.11,-.93,;-6.44,-.16,;-7.21,1.17,;-7.98,-.16,;-1.11,-.16,;.22,-.93,;1.69,-.46,;.44,.45,;.92,1.91,;.15,3.24,;2.46,1.91,;3.23,3.24,;2.93,.45,;3.36,-3.04,;4.9,-3.04,)| | ||
Structure |