Reaction Details | |||
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Target | Amyloid-beta precursor protein | ||
Ligand | BDBM136898 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Release Assay | ||
Temperature | 310.15±n/a K | ||
IC50 | 1.5±n/a nM | ||
Comments | extracted | ||
Citation | Karlstrom, S; Soderman, P; Swahn, B; Rakos, L; Ohberg, L Cycloalkyl ether compounds and their use as BACE inhibitors US Patent US9000185 Publication Date 4/7/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Amyloid-beta precursor protein | |||
Name: | Amyloid-beta precursor protein | ||
Synonyms: | A4 | A4_HUMAN | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid beta Protein | Amyloid beta protein (sAPPbeta) | Amyloid beta protein Abeta(1-42) | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Amyloid protein (Abeta42b) | Amyloid β-protein (Aβ42) | Beta amyloid A4 protein | Beta-APP40 | Beta-APP42 | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma Secretase | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta | beta-Amyloid Precursor Protein (APP) | ||
Type: | Single-pass type I membrane protein | ||
Mol. Mass.: | 86890.41 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P05067 | ||
Residue: | 770 | ||
Sequence: |
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BDBM136898 | |||
n/a | |||
Name | BDBM136898 | ||
Synonyms: | US10231967, Example 126 | US8865911, 126 | US9000185, 6 | US9918985, Example 126 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H31N3O2 | ||
Mol. Mass. | 381.5111 | ||
SMILES | CO[C@H]1CC[C@@]2(Cc3ccc(OCC4CCC4)cc3C22N=C(C)C(N)=N2)CC1 |r,wD:5.5,2.1,c:27,t:23,(7.49,-3.23,;6.72,-1.9,;5.18,-1.9,;4.41,-.57,;2.87,-.57,;2.1,-1.9,;1.2,-3.14,;-.27,-2.67,;-1.6,-3.44,;-2.94,-2.67,;-2.94,-1.13,;-4.27,-.36,;-4.27,1.18,;-5.6,1.95,;-6,3.44,;-7.49,3.04,;-7.09,1.55,;-1.6,-.36,;-.27,-1.13,;1.2,-.65,;-.05,.25,;.43,1.72,;-.34,3.05,;1.97,1.72,;2.74,3.05,;2.44,.25,;2.87,-3.23,;4.41,-3.23,)| | ||
Structure |