Reaction Details | |||
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Target | Fibroblast growth factor receptor 1 | ||
Ligand | BDBM286984 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Caliper-Based Kinase Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.600±n/a nM | ||
Comments | extracted | ||
Citation | Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US9567334 Publication Date 2/14/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Fibroblast growth factor receptor 1 | |||
Name: | Fibroblast growth factor receptor 1 | ||
Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
Type: | Receptor | ||
Mol. Mass.: | 91861.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11362 | ||
Residue: | 822 | ||
Sequence: |
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BDBM286984 | |||
n/a | |||
Name | BDBM286984 | ||
Synonyms: | 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 6 | US11078199, Cpd 6 | US9567334, Example 6 | US9815834, Compound 6 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H30Cl2N6O4 | ||
Mol. Mass. | 561.46 | ||
SMILES | CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-6.67,-.77,;-6.67,.77,;-5.33,1.54,;-5.33,3.08,;-4,3.85,;-2.67,3.08,;-1.33,3.85,;,3.08,;1.33,3.85,;1.33,5.39,;,6.16,;2.67,6.16,;2.67,7.7,;1.33,8.47,;4,5.39,;4,3.85,;5.33,3.08,;6.67,3.85,;2.67,3.08,;2.67,1.54,;,1.54,;1.33,.77,;-1.33,.77,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;1.33,-5.39,;2.67,-6.16,;4,-5.39,;4,-3.85,;2.67,-3.08,;5.33,-6.16,;6.67,-5.39,;5.33,-7.7,;6.67,-8.47,;-2.67,1.54,;-4,.77,)| | ||
Structure |