| Reaction Details |
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 | Report a problem with these data |
| Target | Thioredoxin reductase 1, cytoplasmic |
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| Ligand | BDBM50426071 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In vitro Assay |
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| pH | 7.6±n/a |
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| IC50 | 15400±n/a nM |
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| Comments | extracted |
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| Citation |  Ostaszewski, R; Klossowski, S; Ziuzia, I; Szokalska, A; Swiech, M; Golab, J Esters of (acyloxymethyl)acrylamide, a pharmaceutical composition containing them, and their use as inhibitors of the thioredoxin—thioredoxin reductase system US Patent US9018255 Publication Date 4/28/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Thioredoxin reductase 1, cytoplasmic |
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| Name: | Thioredoxin reductase 1, cytoplasmic |
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| Synonyms: | GRIM-12 | GRIM12 | Gene associated with retinoid-IFN-induced mortality 12 protein | KDRF | KM-102-derived reductase-like factor | TR | TRXR1_HUMAN | TXNRD1 | Thioredoxin reductase 1 | Thioredoxin reductase 1 (TrxR) | Thioredoxin reductase TR1 |
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| Type: | Protein |
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| Mol. Mass.: | 70761.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16881 |
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| Residue: | 648 |
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| Sequence: | MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCG
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| BDBM50426071 |
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| n/a |
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| Name | BDBM50426071 |
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| Synonyms: | CHEMBL406050 | PX-12 | US9018255, PX-12 | med.21724, Compound 156 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H12N2S2 |
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| Mol. Mass. | 188.314 |
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| SMILES | CCC(C)SSc1ncc[nH]1 |
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| Structure | 
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