Reaction Details |
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Target | Thioredoxin reductase 1, cytoplasmic |
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Ligand | BDBM156234 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In vitro Assay |
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pH | 7.6±n/a |
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IC50 | 2800±n/a nM |
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Comments | extracted |
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Citation | Ostaszewski, R; Klossowski, S; Ziuzia, I; Szokalska, A; Swiech, M; Golab, J Esters of (acyloxymethyl)acrylamide, a pharmaceutical composition containing them, and their use as inhibitors of the thioredoxin—thioredoxin reductase system US Patent US9018255 Publication Date 4/28/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Thioredoxin reductase 1, cytoplasmic |
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Name: | Thioredoxin reductase 1, cytoplasmic |
Synonyms: | GRIM-12 | GRIM12 | Gene associated with retinoid-IFN-induced mortality 12 protein | KDRF | KM-102-derived reductase-like factor | TR | TRXR1_HUMAN | TXNRD1 | Thioredoxin reductase 1 | Thioredoxin reductase 1 (TrxR) | Thioredoxin reductase TR1 |
Type: | Protein |
Mol. Mass.: | 70761.78 |
Organism: | Homo sapiens (Human) |
Description: | Q16881 |
Residue: | 648 |
Sequence: | MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCG
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BDBM156234 |
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n/a |
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Name | BDBM156234 |
Synonyms: | US9018255, L-3a |
Type | Small organic molecule |
Emp. Form. | C23H26F6N2O6 |
Mol. Mass. | 540.4528 |
SMILES | CCOC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)C(=C)COC(=O)c1c(cccc1C(F)(F)F)C(F)(F)F |
Structure |
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