| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-secretase-activating protein |
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| Ligand | BDBM157134 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF Biochemical Assay |
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| IC50 | 1.2±0.0 nM |
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| Citation |  Shelton, CC; Tian, Y; Li, Y γ-Secretase substrates and methods of use US Patent US9023767 Publication Date 5/5/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-secretase-activating protein |
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| Name: | Gamma-secretase-activating protein |
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| Synonyms: | GSAP | GSAP_HUMAN | Gamma-secretase | PION |
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| Type: | Protein |
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| Mol. Mass.: | 97808.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | A4D1B5 |
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| Residue: | 854 |
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| Sequence: | MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYT
YKDDKGNVVFGLYDCQTRQNELLYTFEKDLQVFSCSVNSERTLLAASLVQSTKEGKRNEL
QPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQF
RIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYA
DESYNLMFEVPLDISLSNSGFKLVNFGCDYHQYRDKFSKHLTLCVFTNHTGSLCVCYSPK
CASWGQITYSVFYIHKGHSKTFTTSLENVGSHMTKGITFLNLDYYVAVYLPGHFFHLLNV
QHPDLICHNLFLTGNNEMIDMLPHCPLQSLSGSLVLDCCSGKLYRALLSQSSLLQLLQNT
CLDCEKMAALHCALYCGQGAQFLEAQIIQWISENVSACHSFDLIQEFIIASSYWSVYSET
SNMDKLLPHSSVLTWNTEIPGITLVTEDIALPLMKVLSFKGYWEKLNSNLEYVKYAKPHF
HYNNSVVRREWHNLISEEKTGKRRSAAYVRNILDNAVKVISNLEARNLGPRLTPLLQEED
SHQRLLMGLMVSELKDHFLRHLQGVEKKKIEQMVLDYISKLLDLICHIVETNWRKHNLHS
WVLHFNSRGSAAEFAVFHIMTRILEATNSLFLPLPPGFHTLHTILGVQCLPLHNLLHCID
SGVLLLTETAVIRLMKDLDNTEKNEKLKFSIIVRLPPLIGQKICRLWDHPMSSNIISRNH
VTRLLQNYKKQPRNSMINKSSFSVEFLPLNYFIEILTDIESSNQALYPFEGHDNVDAEFV
EEAALKHTAMLLGL
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| BDBM157134 |
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| n/a |
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| Name | BDBM157134 |
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| Synonyms: | US9023767, Compound E |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24F2N4O3 |
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| Mol. Mass. | 490.5013 |
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| SMILES | CC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O |t:19| |
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| Structure | 
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