Reaction Details |
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Target | Gamma-secretase-activating protein |
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Ligand | BDBM157135 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HTRF Biochemical Assay |
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IC50 | 1.0±0.0 nM |
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Citation | Shelton, CC; Tian, Y; Li, Y γ-Secretase substrates and methods of use US Patent US9023767 Publication Date 5/5/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Gamma-secretase-activating protein |
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Name: | Gamma-secretase-activating protein |
Synonyms: | GSAP | GSAP_HUMAN | Gamma-secretase | PION |
Type: | Protein |
Mol. Mass.: | 97808.44 |
Organism: | Homo sapiens (Human) |
Description: | A4D1B5 |
Residue: | 854 |
Sequence: | MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYT
YKDDKGNVVFGLYDCQTRQNELLYTFEKDLQVFSCSVNSERTLLAASLVQSTKEGKRNEL
QPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQF
RIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYA
DESYNLMFEVPLDISLSNSGFKLVNFGCDYHQYRDKFSKHLTLCVFTNHTGSLCVCYSPK
CASWGQITYSVFYIHKGHSKTFTTSLENVGSHMTKGITFLNLDYYVAVYLPGHFFHLLNV
QHPDLICHNLFLTGNNEMIDMLPHCPLQSLSGSLVLDCCSGKLYRALLSQSSLLQLLQNT
CLDCEKMAALHCALYCGQGAQFLEAQIIQWISENVSACHSFDLIQEFIIASSYWSVYSET
SNMDKLLPHSSVLTWNTEIPGITLVTEDIALPLMKVLSFKGYWEKLNSNLEYVKYAKPHF
HYNNSVVRREWHNLISEEKTGKRRSAAYVRNILDNAVKVISNLEARNLGPRLTPLLQEED
SHQRLLMGLMVSELKDHFLRHLQGVEKKKIEQMVLDYISKLLDLICHIVETNWRKHNLHS
WVLHFNSRGSAAEFAVFHIMTRILEATNSLFLPLPPGFHTLHTILGVQCLPLHNLLHCID
SGVLLLTETAVIRLMKDLDNTEKNEKLKFSIIVRLPPLIGQKICRLWDHPMSSNIISRNH
VTRLLQNYKKQPRNSMINKSSFSVEFLPLNYFIEILTDIESSNQALYPFEGHDNVDAEFV
EEAALKHTAMLLGL
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BDBM157135 |
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n/a |
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Name | BDBM157135 |
Synonyms: | US9023767, GSI-34 |
Type | Small organic molecule |
Emp. Form. | C25H24ClFN2O4S2 |
Mol. Mass. | 535.05 |
SMILES | Fc1ccc(OCC(=O)Nc2ccc3CC4CCC(Cc3c2)C4NS(=O)(=O)c2ccc(Cl)s2)cc1 |
Structure |
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