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TargetMitogen-activated protein kinase 1
LigandBDBM157214
Substrate/Competitorn/a
Meas. Tech.IMAP-FP Assay
IC50 0.2512±n/a nM
Citation Lim, JKelley, EHMethot, JLZhou, HPetrocchi, AMansoor, UFFischer, CO'Boyle, BGuerin, DJBienstock, CEBoyce, CWDaniels, MHFalcone, DFerguson, RDFevrier, SHuang, XLipford, KASloman, DLWilson, KZhou, WWitter, DMaletic, MMSiliphaivanh, P Compounds that are ERK inhibitors US Patent US9023865 Publication Date 5/5/2015
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM157214
n/a
NameBDBM157214
Synonyms:US9023865, 60
TypeSmall organic molecule
Emp. Form.C18H15ClFN7O
Mol. Mass.399.809
SMILESCn1cc(cn1)-c1n[nH]c2cc(NC(=O)NCc3ccc(F)c(Cl)c3)ncc12
Structure
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